Process of making a soluble compound of iron-glycero-phosphate combined with milk or milk-albumin.



45 insplssation.

UNITED STATES, PA ENT oFFion PAUL HOERING, F BERLIN, GERMANY.

PROCESS OF MAKING A SOLUBLE COMPOUN D OF IRON-GLYCERO-PHOSPHATE COMBINEDNo Drawing.

Specification of Letters Patent.

Application filed July 7, 1911. Serial No. 637,243.

WITH MILK QB, MILK-ALBUMIN.

Patented May 28,1912.

to an improved process of making a soluble compound ofiron-glycero-phosphate intimately combined with milk or milk albumin. v

I have already disclosed in the British Patent, No. 16,152 of 1907,heretofore ob-' l5 tained by me, that valuable soluble iron-caseincompounds which contain in addition to masked iron glycero-phosphateintimately combined with casein, can be obtained when casein isdissolved in an alkali and the soluspondinq uantit of ironlycero-phosphate. Now I lui ve fOlll ld that s uch iron-albumincompounds can be made very simply, cheaply and inexpensively byproceeding directly from the milk and mixing the same according to itspercentage of albumin with iron-glycero-phosphate. In this case also,just as with the casein-alkali solution, a

conversion to iron-glycerophosphate-casein occurs, which could not beforeseen. A milk of agreeable taste and but little'changed incolor isobtained, which, when unskimmed milk is employed, contains all theconstituents of the milk and, in addition, iron- 3 glycero-phosphatewhich is intimately combined with the milk-albumin. The product is areadily assimilable iron-albumin compound which is of greatphysiological and therapeutic value, as it contalns, in addition 4 tothe albumin of the milk, the valuable iron-glycero-phosphate intimatelycombined therewith. The compound of milk and ironglycero-phosphate thusobtained can be brought into stable form by sterilization or Wheninexpensive skimmed milk is used and evaporated to dryness after theaddition of the iron-glycero-phosphate, for instance, by allowing thesame to run over highly-heated rolls, a yellowish white 00 powder isobtained which dissolves readily in water with milky turbidity. In thismanner a cheap and exceedingly readily assimilable nutrient in a stableand convenient form is obtained, which contains the unchangedconstituents of the milk and also,

4 tion obtained thereby mixed with a corre-- particularly, the properpercentage of masked iron and glycero-phosphate, both intimatelycombinedwith the milk-albumin. ids-compared with other iron-preparations, thispreparation'is advantageously distinguished therefrom by its agreeabletaste.

My improved process represents a considerable improvement over the wellknown processes of making iron-casein compounds, as it is no longernecessary first to separate the casein in an insoluble form, thendissolve it by adding alkali, and then obtain the soluble iron-albumincompounds by adding iron-salts. It is of great importance that in thecompounds prepared according to the present invention, thealbumin-molecule is present in an unchanged form It is well known thatthe proteins are changed by coagulation, for instance, by adding acidsor ferments to the milk, not only with regard to their molecularcomposition, but also by theloss of their physiological prop erties,such as their capability ofbeing readily digested and assimilated.

My present process enables compounds of casein andiron-glycero-phosphate 'to be made in a water-soluble form without, asin the process heretofore disclosed by me, passing them through aninsoluble form, whereby all the intermediate operations and all thechanges in the albumins caused thereby are avoided.

Though milk has heretofore been mixed with solutions ofsodium-glycero-phosphate placed on the market in this form, thecompoundswhich were obtained according to my process, differ verymaterially therefrom inasmuch as according to my invention, simplemixtures or emulsions are not formed, but, in consequence of theconversion, the iron-glycero-phosphate is intimately combined with thealbumin-molecule whereby the great physiological and therapeutic valueof the compounds is obtained.

The preparation according to my invention may be employed either alone,or mixed with cocoa and the like, as a nutrientand strengthening agentwhich can .be readily absorbed.

Example: liters of skimmed milk are mixed, preferably after beingneutralized by an admixture of alkali or alkaline salts, with a quantityof preferably freshly made iron-glycero-phosphate corresponding eitherto the percentage of albumin or to the neu-.

7 tral salt.

tral calcium salt of the same. As skimmed milk contains six-seventhsparts of casein,

' and one-seventh part of globulin and albumin, itis v only necessary toconsider the contents of casein and combine it with the equivalentquantity of iron glycero -phosphate so as to form with the casein a neu-As the average percentage of casein in skimmed milk is 3%, it isnecessary to add for 100 liters of milk the equivalent quantity ofiron-g'lycero-phosphates, namely 282 grams dissolved in about 3 litersof water. By evaporating the solution to. dryness, a yellowish Whitepowder of agreeable odor and taste is obtained.

I claim:

1. The herein described process of making soluble compounds of milk andmilk-albumin, which consists in mixing milk with iron-glycero-phosphate,and evaporating the solution thus obtained to a dry powder.

2. The herein described process of manufacturing soluble iron -m1lkpreparatipns, which consists in mixing milk with a quancity ofiron-glycerophosphate equivalent to the percentage of albumin in themilk, and then evaporating the solution to powder. i

In testimony whereof I aflix hereunto my signature in presence of twoWitnesses.

PAUL HOERING. Witnesses ERNEST ENTENMANN,

FRIDA KLEIBER.

a dry v

